With 45 majors and 56 minors to choose from, Mount Union College offers a wide array of academic coursework in keeping with the liberal arts tradition. Students are encouraged to thoroughly explore a variety of departments and majors to discover potential talents and interests. Through general education course requirements, students are able to test the waters of a variety of majors and minors, allowing students to find a perfect fit. Also, in developing a close relationship with their academic departmental advisor, students are able to find guidance in deciding what majors and minors are most advantageous.

One of the most popular programs for students at Mount Union College is the music program. Students can get involved in many kinds of bands or choirs, including Concert Choir, Mount Union Alliance Chorale, "Fire-Engine" Choir, Opera Workshop, Alliance Symphony Orchestra, Repertory Strings, Marching Band, Jazz Band, Percussion Ensemble, and more.

The Theatre Department puts on two productions every fall, and varying productions in the spring. Every spring semester alternates between a musical and a straight play every year for the main stage show, and every spring there are also student-directed one-acts. Theatre productions are open to all students, regardless of major or class rank.